Metabolotheranostics of pancreatic cancer by targeting choline, glutamine, and glucose transporters with photoimmunotherapy

This dataset contains raw and processed data supporting the findings of the manuscript focused on the metabolotheranostics of pancreatic ductal adenocarcinoma (PDAC) using photoimmunotherapy (PIT). In this work, we exploited the extracellular domains of three metabolic transporters—CTL1 (choline), ASCT2 (glutamine), and GLUT1 (glucose)—as targets for antibody-IR700 conjugate PIT. The repository includes: TCGA Database Analysis: Data establishing the elevated expression profiles of CTL1, ASCT2, and GLUT1 in human PDAC samples. In Vitro PIT Studies: Cell viability assays across patient-derived PDAC cell lines (Pa04C and Pa20C cells) demonstrating transporter expression-dependent cytotoxicity following near-infrared (NIR) light exposure. In Vivo Tumor Models: Data detailing Pa04C tumor response and eradication rates following single-dose targeted CTL1-PIT treatment.