Genomic caracterization of sotorasib-resistant lung tumors in mice

NIAID Data Ecosystem2026-03-14 收录

肿瘤耐药机制

肿瘤治疗基因组学

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https://www.ncbi.nlm.nih.gov/sra/SRP376215 数据链接链接失效反馈

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Comparison of genomic variants in sotorasib-treated / untreated lung tumors in Kras-G12C / Trp53-KO mice

创建时间：

2023-03-05

Targeting tumor-macrophage interaction via the Notch2-Jag1 axis reverses tumor resistance to paclitaxel

肿瘤耐药机制

信号通路靶向治疗

Taxanes are widely used in chemotherapy, but intrinsic and acquired resistance limit the clinical outcomes. Studies showed tumor interaction with suppressive macrophages plays a key role in taxane res

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Suppression of adaptive responses to targeted cancer therapy by transcriptional repression [RNA-seq]. Homo sapiens

肿瘤耐药机制

转录组药物响应

Large-scale genomic profiling efforts have facilitated the characterization of molecular alterations in cancers and aided the development of targeted kinase inhibitors for a wide array of cancer types

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Identifying the downstream effectors of E2F7 in squamous cell carcinoma (SCC) cells

肿瘤耐药机制

分子靶点发现

Advanced head and neck squamous cell carcinomas (HNSCC) are frequently drug resistant and have a mortality rate of 40%. We have previously shown that E2F7 may contribute to drug sensitivity. In the pr

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Gene expression data from rapamycin resistant and sensitive cell lines

肿瘤耐药机制

miRNA调控

The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tum

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YAP activation mediates acquired resistance to ALK inhibitor in ALK rearranged non–small cell lung cancer

肿瘤耐药机制

ALK靶向治疗

To investigate a possible candidate for overcoming the acquired resistance to ALK-TKI, we established an in vitro model of acquired resistance to crizotinib (H3122-CR) by exposing EML4-ALK–positive H3

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Genomic caracterization of sotorasib-resistant lung tumors in mice

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