Cereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide

ChEBI2011-09-30 更新2026-07-21 收录

多发性骨髓瘤靶向治疗

药物机制研究

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Cereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide

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2011-09-30

Triple MAPK inhibition salvaged a relapsed post BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E sub-clonal mutation

多发性骨髓瘤靶向治疗

CAR-T细胞耐药机制

Multiple Myeloma (MM) is a progressive plasma cell neoplasm characterized by heterogeneous clonal expansion. Despite promising response rates achieved with anti-BCMA CAR-T cell therapy, patients may s

NIAID Data Ecosystem70

Top three gene ontology biological processes resulting from the analysis of differential regulated genes between antioxidant drugs and the respective solvent controls.

基因本体富集分析

药物机制研究

This analysis was performed using the DAVID program (see MM). Count indicates the number of genes belonging to the indicated gene ontology biological processes that we found regulated by a factor 2; %

NIAID Data Ecosystem60

Gene expression signatures in oridonin-treated WT and R878H hematopoietic stem cells. Gene expression signatures in oridonin-treated WT and R878H hematopoietic stem cells

药物机制研究

干细胞生物学

Analysis of WT-Ctl v.s. WT-Ori and R878H-Ctl v.s. R878H-Ori hematopoietic stem cell (lineage-, c-kit+ Sca-1+ CD150+, CD34-). The four population of hematopoietic stem cell (HSC) were purified from the

NIAID Data Ecosystem60

Additional file 9: of PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs

多发性骨髓瘤靶向治疗

表观遗传药物响应

Table S5. H3K27me3-associated and EPZ-6438-regulated genes (XLSX 12 kb)

Figshare2018-10-04 更新70

Prolonged halting of gene expression in early G1 arrest by inhibition of CDK4/CDK6 reprograms myeloma cells for cytotoxic killing. Homo sapiens

多发性骨髓瘤靶向治疗

细胞周期调控与凋亡

By selective and reversible inhibition of CDK4/CDK6, we have developed a strategy to both inhibit proliferation and enhance cytotoxic killing of cancer cells. Induction of prolonged early-G1 arrest (p

NIAID Data Ecosystem60

Cereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide

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