Organic-inorganic hybrid based on Laponite as a platform for controlled release of 5-fluorouracil: characterization and release mechanism

In this study, we developed an organic–inorganic hybrid based on Laponite (synthetic clay mineral) modified with APTES ((3-aminopropyl)triethoxysilane) to enhance the controlled release of 5-FU. The structural features of the hybrid are designed to improve drug loading efficiency and modulate the release profile by optimizing interactions between the drug and the modified clay. Comprehensive characterization was performed to elucidate the structural, morphological, and chemical modifications induced by APTES, followed by investigation of the release kinetics and underlying release mechanism. In addition, in vitro cell viability assays and HET Cam assays were conducted to evaluate the biocompatibility of the developed system and assess its potential for biomedical applications. The datas is related to the raw data obtained from characterization of Laponite, Laponite modified with APTES and the hybrid loaded with 5-Fluororacil. As well as the release assay, models used, cell vilability and HET-CAM analysis. The raw datas is in workbooks at Origin Project (.opju) file; Sigma Plot (pzfx); txt, xlsx, docx and pdf.