B12-related parameters measure in mice following 27 days of continuous delivery of saline (control), cobinamide (Cbi) and vitamin B12 (B12) by osmotic minipumps1.

1: The listed values are obtained from samples collected from mice 27 days after subcutaneous insertion of an osmotic minipump delivering 0.9% NaCl (control), 4.25 nmol/h Cbi, or 1.75 nmol/h B12 in 7–week–old female mice of the 129.S6 strain. n = 7 in each group.2: ANOVA tests are carried out between Control and Cbi– or B12–mice (*p3: n = 6 for urine values of control mice.4: The used assay for analysis of Cbi in urine does not allow for determination of small amounts of Cbi in B12–rich samples.ND: Not determined. tHcy: total homocysteine. UB12BC: Unsaturated B12 binding capacity. B12: Vitamin B12 Cbi: cobinamide. Crea: creatinine. MMA: methylmalonic acid.