RNA-seq data to study immune response to SARS-CoV-2 virus infection in COVID-19 Health Action Response for Marines (CHARM) study

RNA-seq data from blood from participants of the COVID-19 Health Action Response for Marines (CHARM) study was generated to study innate immune responses to SARS-CoV-2 infection. We investigate 1. gene expression difference between symptomatic and asymptomatic participants, 2. gene expression difference between male and female participants, 3. how the gene expression and methylation are correlated, 4. change in alternative splicing. Overall design: RNA sequencing was performed on samples collected from 475 subjects at different time points as part of SARS-Cov-2 of initial outbreak and later surveillance on the Marine recruits. 1605 samples were sequenced, and some samples were sequenced in duplicates. In total, there are 1858 RNA-seq data sets in this submission.