NHLBI TOPMed: Genetic Epidemiology Network of Salt Sensitivity (GenSalt)

The GenSalt study aims to identify genes which interact with dietary sodium and potassium intake to influence blood pressure in Han Chinese participants from rural north China. Whole genome sequencing will be conducted among 1,860 participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) Study. We will work in collaboration with participating TOPMed studies to identify novel common, low-frequency and rare variants associated with an array of cardiometabolic phenotypes. In addition, we will explore the relation of low-frequency and rare variants with salt-sensitivity among GenSalt study participants.本GenSalt研究（GenSalt Study）旨在识别中国北方农村汉族受试者中，与膳食钠、钾摄入相互作用进而影响血压的相关基因。本研究将对1860名盐敏感性遗传流行病学网络（Genetic Epidemiology Network of Salt Sensitivity, GenSalt）研究的受试者开展全基因组测序。我们将与参与的TOPMed研究合作，识别与一系列心血管代谢表型相关的新型常见、低频及罕见变异。此外，我们将在GenSalt研究受试者中探讨低频与罕见变异与盐敏感性之间的关联。