Data from: Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal

Adaptive evolution in humans has rarely been characterized for its whole
set of components, i.e. selective pressure, adaptive phenotype, beneficial
alleles and realized fitness differential. We combined approaches for
detecting selective sweeps and polygenic adaptations and for mapping the
genetic bases of physiological and fertility phenotypes in approximately
1000 indigenous ethnically Tibetan women from Nepal, adapted to high
altitude. We performed genome-wide association analysis and tests for
polygenic adaptations which showed evidence of positive selection for
alleles associated with more pregnancies and live births and evidence of
negative selection for those associated with higher offspring mortality.
Lower hemoglobin level did not show clear evidence for polygenic
adaptation, despite its strong association with an EPAS1 haplotype
carrying selective sweep signals.