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The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with Raltegravir

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Protein Data Bank Japan2023-10-25 更新2026-04-19 收录
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The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with Raltegravir Descriptor: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide, ... Authors: Cuypers, M.G, Slavish, P.J, White, S.W, Rankovik, Z. Deposit date: 2021-02-27 Release date: 2021-05-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
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2021-02-27
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