Comparison of methods that use sequences as inputs.

Paragraph and PECAN model the 3D structures from the sequences with ABodyBuilder (ABB) [10], while MIPE uses AlphaFold2 (AF2), and requires both antibody and antigen sequences. All other methods operate directly on sequences without requiring structural modeling. Performance metrics (PR AUC, ROC AUC, F1 score, and MCC) with additional model characteristics (structure modeling free and antigen agnostic) for models evaluated on PECAN, PARAGRAPH, and MIPE datasets. The highest value in each column is in bold, the second best is underlined.