Association between depressive disorder, global seasonality score (GSS), and SNPs of the circadian clock genes in males from the Finnish population.

aSNPs yielding permutated pointwise p-values<0.05 in the single-locus analyses.
bAllele: Major/Minor.
c95% confidence intervals for the odds ratio (OR).
dMinor allele frequency in non-overlapping groups of cases (D+) and controls(D–) stratified by the absence or presence of early morning awakening or fatigue.
eThe P-values for GSS factor 1 (metabolic factor) and factor 2 (mental factor) were generated using the linear regression model. Bold face SNP signify P-values<0.05, β (Regression coefficient)  = 0.069.
D+, patients with depression.
D–, controls (no depression).
D+EMA+, depressed patients with early morning awakening.
D–EMA–, controls without early morning awakening.
D+FAT+, depressed patients with fatigue.
D–FAT–, controls without fatigue.
*Permutation-based corrected empirical P = 0.0374 over the model D+EMA+ vs. D–EMA– when all examined variants (n = 106) were considered.