Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during root development

We show that Ror2 mediated non-canonical Wnt signaling in the dental mesenchyme plays a critical role in cell proliferation and thereby regulates root development size in mouse molars. Furthermore, Cdc42 acts as a potential downstream mediator of Ror2 signaling in root formation. we detected the tooth development in in Ror2 conditional knockout mouse models本研究表明，牙间充质（dental mesenchyme）中由Ror2介导的非经典Wnt信号通路（non-canonical Wnt signaling）在细胞增殖过程中发挥关键作用，并由此调控小鼠磨牙的牙根发育尺寸。此外，Cdc42可作为Ror2信号通路在牙根形成过程中的潜在下游介导因子。我们通过Ror2条件性基因敲除小鼠模型（conditional knockout mouse models）检测了牙齿发育状况。