Containing the Supplementary Tables A to G.

Table A: list of ICD10 codes used to define the T2D complication groups. Table B: summary of the analyses performed with the number of individuals kept, the covariates used for the adjustment and the significance threshold. Table C: Results of the bi-directionnal MR analyses (IVW method) in the 1st and 2nd set of metabolites. Table D: Results of the one-sample MR Forward analysis (ivreg estimate) in the 2nd release set of significant metabolites from the main MR analyses. Table E: Variants significant at the genome-wide significance threshold (5e-8) in the interaction analysis and replicated in the Estonian Biobank (q-value (XLSX)