Expression data from hiPSC derived WT and ISG15 KO endothelial cells stimulated with interferon-a and treated with itaconic acid, dimethyl itaconate, 4-octyl itaconate and ruxolitinib. Expression data from hiPSC derived WT and ISG15 KO endothelial cells stimulated with interferon-a and treated with itaconic acid, dimethyl itaconate, 4-octyl itaconate and ruxolitinib

Analysis of gene expression in WT and ISG15 KO endothelial cells, stimulated with IFNa and treated with Itaconic acid (IA), Dimethyl itaconate (DI), 4-octyl itaconate (4OI) and ruxolitinib (RUX) to investigate the effects of treatments on transcriptional response in the cells. Overall design: WT and ISG15 KO endothelial cells were differentiated from hiPSCs. Endothelial cells were stimulated with interferon-a for 8 hours. Cells were then treated with itaconic acid, dimethyl itaconate, 4-octyl itaconate and ruxolitinib for 16 hours. RNA was extracted, and subjected to transcriptome profiling array Clariom™ S Assay, human.