A decade of discovery: tracing the footmarks of migrasomes, unveiling the footprints of cells

The study of migrasomes, a newly discovered cellular structure, holds great potential for uncovering unknown cellular and molecular mechanisms in intercellular communication and disease processes. Migrasomes, with diameters ranging from 500 nm to 3 μm, form at the cell tail during migration and are subsequently released extracellularly. Their biogenesis involves site determination, membrane swelling and expansion. Migrasomes contain a diverse array of constituents, including nucleic acids, proteins, lipids, nanovesicles, viral particles, and organelles. Migrasomes offer a window into understanding the altered cellular or tissue states, providing novel mechanisms for understanding their physiological and pathological processes. Migrasome detection holds promise for diagnostic applications. The interdisciplinary nature of migrasome research highlights the need for continued integration of cutting-edge technologies, such as multi-omics, advanced microscopy, and bioengineering, to fully explore their biological significance and therapeutic potential.