Single-cell lineage mapping of a diverse virus-specific naïve CD4 T cell repertoire
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE158896
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The naïve polyclonal CD4 T cell repertoire can differentiate into multiple lineages during acute viral infection, with some T cell clones exhibiting a preferred lineage choice. TCR α CDR3 motifs can partially influence a clone-intrinsic lineage preference towards TFH fate. Activated antigen specific CD4 T cells (CD4+CD44+GP66+) were sorted from five C57BL/6J mice and used to perform Single cell gene expression (GEX) and single cell TCR sequencing (TCR) using 10x genomics kit at day 10 post acute LCMV infection
创建时间：
2025-08-27
