Transcriptome analysis of Control and FBXO38 knockdown in HCT116 and Hela cell lines. Transcriptome analysis of Control and FBXO38 knockdown in HCT116 and Hela cell lines

F-box only protein 38 (FBXO38), which belongs to SKP1-CUL1-F-box protein (SCF) family, exhibits the ability to mediate Lys48-linked poly-ubiquitination and subsequent proteasome degradations of PD-1.To investigate the effect of FBXO38 knockdown on transcription in tumor, we constructed control and FBXO38 knockdown by shRNA in Hela and HCT116 cell lines. We found that FBXO38 may interact with the immune pathway in the tumor. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq with control (shscramble) and FBXO38 knockdown (shFBXO38) HCT116 and Hela cells at two times.