Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone

To identify signalling pathways altered by ST6GAL1 in prostate cancer cells, we established DU145 and PC3 stable cell lines in which ST6GAL1 was overexpressed. We then performed differential gene expression, Gene Ontology and GSEA analyses using data obtained from RNA-seq of the control and OE cell lines. Comparative gene expression profiling analysis of RNA-seq data for Lenti-ORF negative control PC3 and DU145 prostate cancer cells vs PC3 and DU145 cells with ST6GAL1 overexpression. Please note that the PC3 samples and updated processed data files have been added to the records on Jan 16, 2025.