Placental proteomics identified elevated Aldo-keto Reductase 1-B1 level in spontaneous preterm birth

The prevalence of preterm birth along with its associated mortality and lifelong morbidity warrant a better understanding of the underlying signaling events for better diagnosis and management of the condition. Placenta is an important transient organ that acts as a conduit between the fetus and mother. Any physiological and pathological changes taking place in the feto-maternal system are directly reflected in the placenta, making it a fitting choice to study the altered signaling mechanisms that are play. We undertook independent data acquisition of clinical placenta samples (n=40), obtained from Garbh-Ini cohort, to study their comparative protein profiles in spontaneous preterm vs term birth condition. When label-free quantitation (LFQ) was carried out, it yielded 23 differentially expressed proteins (DEPs) in the case-control comparison.