PPI-Hotspot

PPI-Hotspot is a database of Protein-Protein Interaction Hot Spots.We have applied the PPI-HotspotDB to create a nonredundant benchmark, PPI-Hotspot+PDBBM, for assessing methods to predict PPI-hot spots using the free structure as input. PPI-HotspotDB will benefit the design of mutagenesis experiments and development of PPI-hot spot prediction methods.PPI-Hotspot是一款蛋白质-蛋白质相互作用热点（Protein-Protein Interaction Hot Spots）数据库。本研究基于PPI-HotspotDB构建了非冗余基准数据集PPI-Hotspot+PDBBM，用于评估以游离蛋白质结构作为输入的蛋白质相互作用热点预测方法。PPI-HotspotDB将为诱变实验设计以及蛋白质相互作用热点预测方法的开发提供助力。