A pilot study on inappropriate use of proton pump inhibitors at a general hospital in Japan

The over-prescription of proton pump inhibitors (PPIs) has become a global clinical issue. We conducted a retrospective study to investigate the trend in PPI prescriptions in a general hospital in Japan and propose the proper use of PPIs with official indications. This study included inpatients at a general hospital between December 2017 and March 2018 who were prescribed oral PPIs (lansoprazole, esomeprazole, and vonoprazan). A pharmacist reviewed electronic medical records (such as referral letters from other hospitals and current medical history) for each extracted patient to see if they met the criteria and divided them into two categories, \"appropriate use\" and \"inappropriate use.\" The criteria for \"appropriate use\" were defined as official indications and generally accepted off-label uses. A pharmacist reviewed the survey results. The primary outcome was the percentage of inappropriate use of oral PPIs among patients. Of the 334 eligible patients, 39% used oral PPIs inappropriatel..., , , # A pilot study on inappropriate use of proton pump inhibitors at a general hospital in Japan

[https://doi.org/10.5061/dryad.q2bvq83t4](https://doi.org/10.5061/dryad.q2bvq83t4)

Author(s)

Naoto Nakagawa, Phar.D., Ph.D.
School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan
31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
Email: [[e-mail]](mailto:[e-mail])

Keita Odanaka, Ph.D.
School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan
31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
Email: [[e-mail]](mailto:[e-mail])

Yoshitaka Okubo, BS, RPh.
Department of Pharmacy, Sendai Tokushukai Hospital, Sendai, Miyagi, Japan
9-8 Takadamacho, Izumi-ku, Sendai, Miyagi 981-3116, Japan
Email: [[e-mail]](mailto:[e-mail])

Tsutomu Ogata, BS, RPh

Department of Pharmacy, Sendai Tokushukai Hospital, Sendai, Miyagi, Japan...