Novel Therapies to Treat Resistant Focal Segmental Glomerulosclerosis: Phase II Clinical Trial

Therapeutic interventions for the treatment of Focal Segmental Glomerulosclerosis Clinical (FSGS) have been widely reported. However, evidence-based treatment guidelines have not been developed because of the lack of controlled studies and the small number of participants included in most reports. The FSGS Clinical Trial (FSGS-CT) was a multi-center, prospective, controlled, open label randomized trial designed to determine if treatment with mycophenolate mofetil (MMF) in conjunction with pulse steroids is superior to treatment with Cyclosporine-A (CSA) in inducing remission from proteinuria over 12 months. The rationale and background related to each of the drugs chosen to be a part of the FSGS-CT therapeutic interventions are outlined in the study protocol.