Cardiac-tbx20 overexpression enhances heart regeneration by promoting cardiomyocytes dedifferentiation and endocardial activation

The goal of this study is to understand the function of cardiac tbx20 during heart regeneration. By high-throughput sequencing, molecular variations of tbx20-cardiac specific inducing heart in response to heart injury compared with control hearts were demonstrated. We collected the injured heart apex tissue at 7 days post injury and sequenced the transcriptome. Overall design: RNA was extracted from ventricular apical portions at 7 days post injury from control hearts and tbx20-cardiac-specific inducing hearts. Tissue from 6-8 zebrafish were collected in each control group or cardiac-tbx20-overexpressing group, three replications were carried out.