Epigenetic fingerprint of the SARS-CoV-2 infection in the lung of lethal COVID-19

This dataset is related to the “Epigenetic fingerprint of the SARS-CoV-2 infection in the lung of lethal COVID-19”study (PMID: 37914026; DOI: 10.1016/j.chest.2023.10.032) , where we interrogated the DNA methylation landscape from lung autopsies of 36 patients who died of SARS-CoV-2 infection vs 18 control individuals.

Information included in this dataset:

1. Differentially methylated CpG sites in COVID-19 vs control group.
2. Differentially methylated CpG sites in chronic vs acute diffuse alveolar damage (DAD) from EPILUNG signature in COVID-19 group.
3. Differentially methylated CpG sites within coding genes between COVID-19 and control groups.
4. Differentially methylated CpG sites within coding genes in COVID-19 vs control groups that significantly correlate with gene expression.
5. Enrichment analysis results from the 160 genes differentially methylated in COVID-19 vs control groups that shown a significant correlation between methylation and expression.