Brain unbound fractions obtained using either the brain slice or the brain homogenate method and in vitro and in vivo unbound brain/plasma ratios of 30 drugs.
收藏Figshare2015-12-02 更新2026-04-29 收录
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In vivo Cu,br/Cu,pl were obtained from total brain plasma ratios (Cbr/Cpl) by using in vitro fu,br from either brain slice or brain homogenate and fu,pl according to: Cubr/Cupl = Cbr/Cpl×fubr/fupl. In vivo values were considered to approach steady-state when the time when samples were taken after at least 3.5 half-lives.
创建时间：
2015-12-02
