Gene expression changes in medulloblastoma due to Myc overexpression and Mitotic inhibition with AZD1152 Aurora Kinase B Inhibitior. Gene expression changes in medulloblastoma due to Myc overexpression and Mitotic inhibition with AZD1152 Aurora Kinase B Inhibitior

Sonic hedgehog medulloblastoma cells with stable overexpression of Myc (UW426-Myc) become sensitized to apoptosis induction when exposed to Aurora kinase B inhibitor AZD1152. We sought to determine the gene expression changes that take place when Myc is overexpressed in UW426 and to determine the genes differentially expressed in UW426-Myc cells compared to wild-type UW426 when exposed tothe drug AZD1152 that specifically inhibits Aurora kinase B activity. Overall design: Expression profiles were generated on the Illumina Human HT-12 v4.0 BeadChip platform for UW426-Myc and UW426 cells grown in standard culture media and exposed to no drug, 0.01% DMSO vehicle, or 100 nM AZD1152-HQPA for 48 hrs