Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo [ChIP-Seq]
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
下载链接：
http://data.iscr.ac.cn/Article?id=24ad714b6cafd06cc72ff0893f0ec0a6
下载链接
链接失效反馈官方服务：
资源简介：
Recent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
提供机构：
Baylor College of Medicine
创建时间：
2022-02-20
