Enantio- and Diastereoselective Betti/aza-Michael Sequence: Single Operated Preparation of Chiral 1,3-Disubstituted Isoindolines
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https://figshare.com/articles/dataset/Enantio-_and_Diastereoselective_Betti_aza-Michael_Sequence_Single_Operated_Preparation_of_Chiral_1_3-Disubstituted_Isoindolines/5450575
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资源简介：
The first enantio-
and diastereoselective Betti/intramolecular
aza-Michael sequence carried out using a C3-symmetric chiral trisimidazoline organocatalyst is reported. The
reaction of phenols and N-tosylimines bearing a Michael
acceptor moiety afforded densely functionalized 1,3-disubstituted
isoindolines bearing two stereogenic centers as single diastereomers
in high yields (≤93%) and excellent enantioselectivities (≤99.9%).
创建时间：
2017-09-28
