Mitochondrial regulator PGC-1a in neuronal metabolism and brain aging

The brain is a high-energy tissue, and brain-resident cell types are distinct in function and in metabolic requirements. The basis for cell-type-specific metabolic status and metabolic adaptation with age has not been well established. This proteomics analysis allows us to better understand how the brain responds to age, which we then leverage as an intervention point throughout the study. This dataset was derived from male mice at three different ages (10 months, 20 months, and 30 months).