Global profiling of protein lysine lactylation in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common types of tumors in adults, with an estimated 740,000 people dying every year. The characteristics of lactic acid protein modifications in HCC remain unknown. Our research team, through the whole protein high flux lactic acid group, study analyses 3 cases of normal liver tissue, 3 cases were followed up for 3 years not metastatic HCC tissue, 3 cases of HCC metastasis tumors that spread to the lungs, has presented the integrity of the generation of HCC and lung metastasis lactic acid modified map, in order to find protein lactate modification targets related to HCC formation and lung metastasis in the future. Protein lactation (Kla) is a novel type of PTM discovered in 2019. Lactate, the end-product of glycolysis, is both metabolite and a signaling molecule. Moreover, studies have shown that lactic acid serves as both an energy source for tumor tissues and mediates histone lysine lactation as a modification substrate. Protein lactate modification has been shown to play a role in inflammation, neurodevelopment, and the occurrence and development of tumors