DNA Damage-Induced Nuclear STING Translocation Orchestrates Innate Immune Activation and Chromatin Remodeling [RNA-Seq]

To define STING's role in the DNA damage response, we collected STING wild-type (WT) and STING knockout (KO) HeLa cells following 24 hours of BMN673 treatment, as well as non-treated cells. We then performed gene expression profiling analysis using data obtained from RNA-seq dataset across four conditions: STING WT and STING KO cells, with or without 24 hours of BMN673 treatment. Overall design: Comparative gene expression profiling analysis of RNA-seq data for STING WT and STING KO HeLa cells after 24 hours of BMN673 treatment or in the non-treated condition. Comparative gene expression profiling analysis of RNA-seq data for STING WT and STING KO HeLa cells after 24 hours of BMN673 treatment or in the non-treated condition.