Data Sheet 1_Ferroptosis research based on bibliometric and visual analysis: mechanism exploration and clinical application prospects in gastric cancer, prostate cancer, leukemia, and brain tumors.docx

PurposeFerroptosis, iron-dependent cell death, holds significant therapeutic potential in oncology. This study aimed to map global research trends (2014–2024) of ferroptosis in gastric cancer, prostate cancer, leukemia, and brain tumors via bibliometric analysis, identifying key developments and clinical prospects.
MethodsPublications from Web of Science, Scopus, and PubMed were analyzed using VOSviewer, CiteSpace for output, collaborations, influential authors/works (co-citation), and keyword trends (burst detection).
ResultsResearch output surged, led by China and the USA. Foundational authors (Dixon, Yang, Stockwell) were highly co-cited. Emerging hotspots include overcoming therapy resistance, tumor microenvironment modulation, immunotherapy integration, and nanotechnology applications. Cancer-specific foci like GPx4 (gastric) and p53 (prostate) pathways were evident.
ConclusionThis analysis provides a comprehensive map of the evolving ferroptosis research landscape across these four cancers, revealing a distinct shift towards translational applications. The findings of this study provide a valuable framework for guiding future research and for the prioritization of clinical strategies targeting ferroptosis.