Phosphorylation of CRMPs by GSK3beta

The phosphorylation of CRMPs at Ser522 allows the subsequent phosphorylation of CRMP1, CRMP2 and CRMP4 at Ser518, Thr509, and Thr514 mediated by serine/threonine kinase GSK3beta. Phosphorylation of CRMP by GSK3beta results in decreased CRMP affinity for beta-tubulin and changes in microtubule dynamics.

CRMPs在Ser522位点的磷酸化作用，使得CRMP1、CRMP2和CRMP4在Ser518、Thr509和Thr514位点发生后续磷酸化，此过程由丝氨酸/苏氨酸激酶GSK3beta介导。GSK3beta对CRMP的磷酸化作用导致CRMP与β-微管蛋白的亲和力降低，并引起微管动力学的变化。