Type of the Paper.docx

Duchenne Muscular Dystrophy (DMD) is a progressive neuromuscular disorder where early cardiovascular involvement significantly contributes to morbidity and mortality. Despite advances in cardiac monitoring, there remains a need for easily accessible biomarkers to predict subclinical cardiac involvement. In this retrospective study, we evaluated the potential prognostic value of systemic inflammatory indices (NLR, PLR, MLR, SIRI, SII, and PIV) in children with DMD and investigated their association with electrocardiographic and echocardiographic findings. Our key findings include: A strong positive correlation between Pro-BNP levels and PLR values (r = 0.86, p < 0.05), suggesting that platelet-to-lymphocyte ratio may reflect underlying cardiac stress. While overall inflammatory indices did not significantly differ between DMD patients and controls, the observed link between PLR and cardiac biomarkers may offer insights into early detection strategies for cardiac involvement in this vulnerable population. We believe our manuscript offers a novel contribution to the growing body of literature on cardiovascular monitoring in DMD by highlighting the potential utility of simple, cost-effective inflammatory markers in risk stratification. This manuscript is original, has not been published previously, and is not currently under consideration by any other journal. All authors have read and approved the final manuscript and meet the criteria for authorship.