Total Synthesis of the Neotropical Poison-Frog Alkaloid (−)-205B
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资源简介：
A stereocontrolled total synthesis of the neotropical poison-frog alkaloid (−)-205B (1) has been achieved, employing a dithiane three-component linchpin coupling, a one-pot sequential construction of the embedded indolizidine ring, and ring-closing metathesis (RCM) to arrive at the novel 8b-azaacenaphthylene ring system comprising the alkaloid. The synthesis proceeded with a longest linear sequence of 19 steps, affording (−)-1 in 5.6% overall yield.
创建时间：
2016-05-05
