Klf5

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; MRF binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of DNA-templated transcription; and skeletal muscle tissue regeneration. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human KLF5 (KLF transcription factor 5). [provided by Alliance of Genome Resources, Nov 2024]

激活DNA结合转录因子活性，RNA聚合酶II特异性；MRF结合活性；以及RNA聚合酶II顺式调控区序列特异性DNA结合活性。在多个过程中发挥作用，包括细胞对白血病抑制因子的响应；DNA模板转录的调控；以及骨骼肌组织的再生。位于细胞核内。为转录调控复合体的一部分。在多个结构中表达，包括早期胚胎；泌尿生殖系统；肠道；呼吸系统；以及感觉器官。与人源KLF5（KLF转录因子5）同源。[由基因组资源联盟提供，2024年11月]