Screening programme efficacy and cost.

We identified index cases with either universal screening of 1–2-year-olds for five years or FAMCAT2 screening of electronic healthcare records and applied cascade screening, using a number of relatives per index case determined from previous studies (see Table 2). It is clear that screening programmes that identify a higher proportion of relatives per index case are more efficacious and more cost-effective and that screening of electronic healthcare records outperforms universal screening.