Brain Catalog

Brain Catalog is a comprehensive resource for genetic landscape of brain disorders and related phenotypes. Currently, Brain Catalog includes the following components: 1. Variant annotation by three software VEP, snpEff and ANNOVAR. 2. Gene-based and gene set analysis by MAGMA. 3. Heritability, heritability enrichment and heritability correlation analysis by two software LDSC and LDAK. 4. Enrichment analysis of associated-trait loci in regulatory and functional annotations by GARFIELD and S-LDSC. 5. Finemapping analysis by four fine-mapping methods ABF, FINEMAP, SuSiE and PolyFun + SuSiE. 6. Gene-based TWAS association by three software S-PrediXcan, UTMOST and JTI. 7. Causal inference and colocalization between six kinds of molecule-QTLs and brain traits, and also the causal effect of exposure traits on outcome traits.Brain Catalog（大脑目录）是一款针对脑部疾病遗传图谱与相关表型的综合性研究资源。目前，Brain Catalog包含以下组成部分： 1. 由VEP、snpEff、ANNOVAR三款软件完成的变异注释； 2. 采用MAGMA开展基因层面与基因集层面的分析； 3. 借助LDSC与LDAK两款软件实现遗传力、遗传力富集度及遗传力相关性分析； 4. 利用GARFIELD与S-LDSC对关联性状位点开展调控与功能注释层面的富集分析； 5. 采用ABF、FINEMAP、SuSiE以及PolyFun + SuSiE四种精细定位方法开展精细定位分析； 6. 通过S-PrediXcan、UTMOST与JTI三款软件完成基于基因的转录组全关联分析（TWAS, Transcriptome-Wide Association Study）； 7. 针对六种分子数量性状位点（molecule-QTLs）与脑部性状之间开展因果推断及共定位分析，同时探究暴露性状对结局性状的因果效应。

搜集汇总

背景与挑战

背景概述

Brain Catalog是一个综合性资源，用于研究脑部疾病及相关表型的遗传图谱。该数据集整合了变异注释、基因分析、遗传力评估、功能富集分析、精细定位、转录组关联分析以及因果推断等多种分析方法，以支持脑部遗传特征的全面探索。