Insights from a Methylome-Wide Association Study of Antidepressant Exposure

Results datasets from the paper: Insights from a Methylome-Wide Association Study of Antidepressant Exposure Methylome-wide association study (MWAS) summary statistics: All individuals: MWAS of prescription-derived antidepressant exposure (n = 7,951): GRM_unadjusted_antidep_pheno1_clean_appt_MOA_ORM_residph_standard_06_10.moa MWAS of self-reported antidepressant exposure (n = 16,531): GRM_unadjusted_selfrep_pheno3_MOA_ORM_residph_standard_06_10.moa Individuals with a lifetime status of Major Depressive Disorder (MDD, MDD-subgroup): MWAS of prescription-derived antidepressant exposure (n = 792) GRM_unadjusted_antidep_pheno2_clean_appt_MOA_ORM_residph_standard_06_10.moa MWAS of self-reported antidepressant exposure (n = 2,268): GRM_unadjusted_selfrep_pheno4_MOA_ORM_residph_standard_06_10.moa Downstream functional analyses: Differentially methylated region (DMRFF) analysis: Prescription-derived antidepressant exposure: antidep_pheno1_clean_appt_dmr_res.tsv Self-report antidepressant exposure: selfrep_pheno3_dmr_res.tsv GO Biological Pathway (msigdbr) enrichment: Prescription-derived antidepressant exposure: gtex_v8_ts_DEG_PD.txt Self-report antidepressant exposure: gtex_v8_ts_DEG_SR.txt SynGo pathway (web-portal) enrichment: Prescription-derived antidepressant exposure: syngo_annotations_matching_user_input_PD.xlsx syngo_ontologies_with_annotations_matching_user_input_PD.xlsx Self-report antidepressant exposure: syngo_annotations_matching_user_input_SR.xlsx syngo_ontologies_with_annotations_matching_user_input_SR.xlsx Tissue enrichment (FUMA GENE2FUNC): Prescription-derived antidepressant exposure: gtex_v8_ts_DEG_PD.txt Self-report antidepressant exposure: gtex_v8_ts_DEG_SR.txt Antidepressant exposure methylation profile score (MPS): GS_AD_MRS_weights.txt Source Data: Source data for Figures and Supplementary Figures which do not represent individual-level data. source_data.xlsx