Integrated profiling of SETD8-driven H4K20me1 in OCCC

This dataset presents an integrated epigenomic and transcriptomic analysis of SETD8-mediated H4K20me1 in ovarian clear cell carcinoma (OCCC). Using ChIP-seq and RNA-seq across multiple OCCC cell lines (ES2, OVTOKO, OVISE, RMG-I), we identified genome-wide H4K20me1 enrichment patterns and their association with gene expression changes. Comparative analysis with other tumor subtypes highlights OCCC-specific chromatin regulatory features driven by SETD8. These data provide insights into how SETD8-dependent histone methylation shapes the unique epigenetic landscape of OCCC and supports functional gene programs.