Synthetic RNA Silencing of Actinorhodin Biosynthesis in <i>Streptomyces coelicolor</i> A3(2)
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We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and metabolic engineering studies in Streptomyces.
创建时间：
2013-06-27
