Orthogonal Strapping of <i>o</i>‑Haloaryl Ynones with Pyrazolones: A One-Pot, Domino Process toward Spiropyrazolones
收藏NIAID Data Ecosystem2026-03-12 收录
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资源简介：
A new class of spiroannulated pyrazolone scaffolds have been assembled from diverse o-haloaryl ynones and β-bromoalkenyl ynones via base mediated, one-pot, metal free, orthogonal strapping (tethering) mediated by the recursive anion(s) derived from pyrazolones. These convenient, preparatively useful transformations proceed through either a tandem Michael addition–intramolecular SNAr reaction or a tandem Michael addition–intramolecular AdNE process to furnish a range of pharmacophoric, diverse, spiroannulated pyrazolones from readily accessible precursors.
创建时间：
2020-10-12
