Rhodium(III)-Catalyzed C–H Activation and Annulation with 1‑Alkynylphosphine Sulfides: A Mild and Regioselective Access for the Synthesis of Bulky Phosphine Ligands
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https://figshare.com/articles/dataset/Rhodium_III_Catalyzed_C_H_Activation_and_Annulation_with_1_Alkynylphosphine_Sulfides_A_Mild_and_Regioselective_Access_for_the_Synthesis_of_Bulky_Phosphine_Ligands/2097439
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资源简介：
We
reported herein rhodium(III)-catalyzed C–H activation
and annulation reactions for the synthesis of bulky phosphine ligands
by using 1-alkynylphosphine sulfides as key starting materials. In
the presence of [Cp*RhCl2]2 (5 mol %) and CsOAc
(2.0 equiv), various N-(pivaloyloxy)benzamides (3.0
equiv) could react smoothly with 1-alkynylphosphine sulfides at 40
°C in MeOH/CF3CH2OH cosolvent without external
oxidant. Using [CpPhRhCl2]2 as catalyst, the reaction can be performed under less loading
of benzamides (2.0 equiv) and milder reaction conditions (25 °C)
with higher regioselectivity. In a sequential cyclization/desulfidation
process, this new method provides a variety of bulky heteroarylphosphines
with an isoquinolin-1(2H)-one motif.
创建时间：
2016-02-12
