The 72-member constrained gene subnetwork is enriched for canonical pathways reflecting neuronal and immune functionality and basic aspects of cell cycle control.

We tested pathways from two sources (the Reactome database and KEGG, the Kyoto Encyclopedia of Genes and Genomes), assessing how many genes are in each pathway (All), how many map onto the 9729 inteconnected genes in our analysis (Mapped), and how many are present in the constrained subnetwork (Subnetwork). We assess significance using both the GSEA approach of a Kolmogorov-Smirnov (KS) test and a simple hypergeometric (HG) test of expected overlaps.