Crystal Structure of Human Beta Secretase in Complex with NVP-BXQ490
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Crystal Structure of Human Beta Secretase in Complex with NVP-BXQ490 Descriptor: (3S,4S,5R)-3-{4-amino-3-fluoro-5-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]benzyl}-5-[(3-tert-butylbenzyl)amino]tetrahydro-2H-thiopyran-4-ol 1,1-dioxide, Beta-secretase 1 Authors: Rondeau, J.M, Bourgier, E. Deposit date: 2012-01-10 Release date: 2012-11-21 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides J.Med.Chem., 55, 2012
创建时间：
2012-01-10
