Separation of the transcriptional coactivator and antirepression functions of transcription factor IIA.
收藏PubMed Central1996-06-25 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC39068/
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资源简介：
Human transcription factor IIA (TFIIA) is composed of three subunits (alpha, beta, and gamma). TFIIA interacts with the TATA-box binding protein and can overcome repression of transcription. TFIIA was found to be necessary for VP16-mediated transcriptional activation through a coactivator function. We have separated the coactivator and antirepression activities of TFIIA. A TFIIA lacking the alpha subunit was isolated from HeLa cells. This "mini-TFIIA" interacts with the TATA-box binding protein and can overcome repression of transcription, but it is defective in transcriptional coactivator function. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-06-25
