Km and Vmax values for CYP3A4 and CYP2B6 enzymes with different mutants of POR were determined by their specific substrates testosterone and bupropion.
收藏Figshare2015-12-02 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_Km_and_Vmax_values_for_CYP3A4_and_CYP2B6_enzymes_with_different_mutants_of_POR_were_determined_by_their_specific_substrates_testosterone_and_bupropion_/295661
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The ratio of Vmax to Km was used as an index of catalytic efficiency; the activity of each POR mutant co-expressed with CYPs was calculated and expressed as a percentage of the activity of wild-type POR, arbitrarily set at 100%.The data were represented as mean ± S.D. of three independent experiments.CLint = Vmax/Km.*: p#: pDash (–) indicates not detectable.
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2015-12-02
