Effect of 24-hour sleep deprivation on cerebral hemodynamics and cognitive performance

Sleep deprivation (SD) is associated with decreased cognitive performance, but the underlying mechanisms are poorly understood. To assess the impact of SD on cerebral hemodynamics in the frontal lobe, functional near-infrared spectroscopy (fNIRS) measurements were carried out on young subjects. Ten young healthy adults (males, age of 27.6±3.7 years, one left-handed participant) were recruited for this study conducted in 2018 at University of Oklahoma, Translational Geroscience Laboratory. The examination protocol began with assessment of cognitive performance with the aid of Cambridge Neuropsychological Test Automated Battery (CANTAB). The following tests were used: motor screening task, rapid visual processing, reaction time, spatial working memory, paired associated learning, and delayed matching to visual sample. Subsequently fNIRS measurements were taken from participants while carrying out a finger-tapping exercise. Each subject was presented with an auditory command to perform a finger-tapping task over three sets of 10 seconds using the left index finger and three sets of 10 seconds using the right index finger, with 10 seconds inter-stimulus periods between each task. Functional NIRS recordings were acquired using a NIRScout platform (NIRx Medical Technologies LLC, NY, USA). Relative oxy- and deoxyhemoglobin time series can be obtained from measured intensities by applying differential modified Beer Lamber Law. All measurements were performed before and after 24 hours of SD. The dataset forms the basis for two studies that explore: (1) the relationship between sleep deprivation, cognitive performance, and neurovascular coupling response in young healthy adults; and (2) sleep deprivation and functional connectivity of the frontal cortex.

睡眠剥夺（SD）与认知功能下降相关，但其潜在机制尚不明确。为评估睡眠剥夺对额叶脑血流动力学的影响，本研究于2018年在俄克拉荷马大学转化老年病学实验室对年轻受试者进行了功能性近红外光谱（fNIRS）测量。本研究招募了十名年轻健康成年人（男性，平均年龄27.6±3.7岁，其中一名左撇子）参与。实验方案始于利用剑桥神经心理学测试自动化电池（CANTAB）评估受试者的认知功能。随后进行的测试包括运动筛选任务、快速视觉处理、反应时间、空间工作记忆、配对关联学习和视觉样本的延迟匹配。紧接着，在受试者进行手指敲击练习时进行了fNIRS测量。每位受试者均接受了听觉指令，要求使用左手食指和右手食指分别进行三组10秒的手指敲击任务，每组任务之间间隔10秒。功能性NIRS记录使用NIRScout平台（NIRx Medical Technologies LLC，纽约，美国）获得。通过应用微分改良比耳定律，可从测量的强度中获得相对氧合血红蛋白和脱氧血红蛋白的时间序列。所有测量均在24小时睡眠剥夺前后进行。该数据集构成了两个研究的基石，这两个研究分别探讨了：（1）睡眠剥夺、认知功能和神经血管偶联反应在年轻健康成人之间的关联；（2）睡眠剥夺与额叶皮层功能连接性。