Sex differences in cardiac aging in mice and development of a female murine model of hypertensive disease in the elderly

C57Bl6/J male and female mice were gonadectomized or not at the age of 12 months and then euthanized 12 months later at the age of 24 months. Half of the females received for 28 days an angiotensin II (AngII; 1.5 mg/kg/day) continuous infusion starting at the age of 23 months. The mice were provided with a running wheel during the 12 months after gonadectomy with the exception of the last month before euthanasia. Comparative gene expression profiling analysis of RNA-seq data for mouse left ventricle samples of both sexes (M or F) from various groups (Controls (Ctr) or Gonadectomised (Gx)) at the age of 24 months. Half of the females were treated for with Angiotensin II(AngII) 4 weeks before euthanasia .