Carbapenem resistant Klebsiella aerogenes at a tertiary care medical center Genome sequencing and assembly

Klebsiella aerogenes are significant nosocomial pathogens associated with outbreaks in intensive care units (ICUs). In 2017, a group of carbapenem-resistant Klebsiella aerogenes was cultured from patients in our cardiac ICU (CICU). Whole genome sequencing (WGS) of CR-EA isolates was undertaken to investigate patient-to-patient transmission, assess phylogeny relative to global strains, and characterize molecular determinants of resistance and virulence.